The Los Angeles Rams and San Francisco 49ers play on Thursday, Dec. 12 at the 49ers’ Levi’s Stadium in the first game on the NFL Week 15 schedule.
Which team will win the Thursday Night Football game?
Check out these NFL Week 15 picks and NFL Week 15 predictions for the game, which can be seen at 6:15 p.m. MST on Prime Video (stream on Amazon).
The 49ers are a 2-point favorite over the Rams in NFL Week 15 odds for the game, courtesy of BetMGM Sportsbook.
San Francisco is -125 on the moneyline, while Los Angeles is +105.
The over/under (point total) is set at 48.5 points.
NFL Week 15 picks: Rams vs 49ers | Cowboys vs Panthers | Chiefs vs Browns | Dolphins vs Texans | Jets vs Jaguars | Commanders vs Saints | Ravens vs Giants | Bengals vs Titans | Patriots vs Cardinals | Colts vs Broncos | Steelers vs Eagles | Bills vs Lions | Buccaneers vs Chargers | Packers vs Seahawks | Bears vs Vikings | Falcons vs Raiders | The Arizona Republic’s predictions
Watch Rams at 49ers live on Amazon
Jeremy Cluff writes: “The Rams beat the 49ers at home in Week 3, 27-24. We expect a similar game this week. This is a must-win game for the 49ers are we expect them to play like it.”
NFL power rankings Week 15:Where are 49ers, Rams now?
Bookies.com: Bet the Rams with the points vs 49ers
Bill Speros writes: “The post-Super-Bowl-hangover has claimed its latest victim in the San Francisco 49ers. The team never recovered from its 25-22 OT loss to the Chiefs in Super Bowl 58. The 49ers were hit hard with injuries this season, as well. Christian McCaffrey is done for the season after suffering a torn PCL this past week. And his backup Jordan Mason may not see action until the 2025-26 season. Even fully staffed, opposing coordinators were able to decipher Kyle Shanahan’s offense. The 49ers routed the Bears in Week 14. But does that even count? The 49ers have failed to cover in 9 straight games after a win. The Rams put up 44 points on the Bills and barely survived in a 2-point win. The trio of Matthew Stafford, Puka Nacua, and Cooper Kupp are back in top form. The Niners’ 38-13 win over the Bears was more mirage than harbinger. The Rams offense can handle San Francisco’s defensive front. And no one appears able to cover Kupp and Nacua these days. And stop Kyren Williams at the same time. And Brock Purdy is no Josh Allen.”
NFL playoff picture Week 15:Where are Rams, 49ers now?
The site’s formula predicts that the 49ers will win the NFL Week 15 game against the Rams.
NFL Week 15 odds:Point spreads, moneylines, over/unders for betting on games this week
ESPN: 49ers have a 60.6% chance to beat Rams on Thursday Night Football
The site gives the Rams a 39% shot at winning the NFL Week 15 game, with the remaining percentage accounting for a tie.
NFL Week 15 schedule:How to watch Rams vs 49ers game
Dimers: 49ers 26, Rams 21
It writes: “After extensive simulations, our model gives the Rams a win probability of 29%, while the 49ers have a win probability of 71%.”
Matt Johnson writes: “Both the Los Angeles Rams and San Francisco 49ers are coming off big wins, providing some momentum for each side for this Thursday Night Football matchup. San Francisco did get cornerback Charvarius Ward back in Week 14, giving this secondary two corners it can trust in man coverage. However, the Rams’ pass rush combined with an effective run game versus a 49ers’ defense that allowed 131.8 rush ypg and 4.5 ypc from Weeks 5-13 should pave the way to a win for Los Angeles.”
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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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